GREENGARD, PAUL


GREENGARD, PAUL
GREENGARD, PAUL (1925– ), U.S. neuroscientist and Nobel laureate. Greengard was born in New York City, where he received his primary education. After World War II service in the Navy, he graduated in mathematics and physics from Hamilton College (1948) and gained his Ph.D. (1953) from Johns Hopkins University, Baltimore, under the guidance of Frank Brink and Sidney Colowick. After postdoctoral studies at the universities of London, Cambridge, and Amsterdam, with Wilhelm Feldberg at the National Institute for Medical Research in Mill Hill, London, and with Sidney Udenfriend at the National Institutes of Health, Bethesda (1953–59), he became director of the Department of Biochemistry in Geigy's Research Laboratories in Ardsley, New York (1959–67). After one year as visiting professor during which he worked with Alfred Gilman and Earl Sutherland, he was appointed professor of pharmacology and psychiatry at Yale University (1968–83). In 1983 he became professor and head of the Laboratory of Molecular and Cellular Neuroscience at the Rockefeller University, New York. Greengard's research interest in neuroscience was inspired by Allen Hodgkin's lecture on nerve conduction at Johns Hopkins, where Greengard was a graduate student. Greengard's work addressed the process whereby signals are transmitted between nerve cells across the synapses which separate them and the role of fast and slow chemical neurotransmitters in neurotransmission. Novel findings were largely built on his entirely vindicated conviction that biochemical and biophysical events in the transmission across the synapses between nerve cells have to be analyzed in tandem. He and his colleagues concentrated on slow transmission by dopamine to analyze biochemical and physiological events on both sides of the synapse during neurotransmission and thereby discovered a key molecule in dopamine signaling called DARPP-32. These and other observations helped to build up a detailed picture of the mediators, structures, and signaling involved in trans-synaptic transmission whereby slow neurotransmitters serve to modulate fast transmission. His work has major implications for diseases involving the dopamine system such as Parkinson's disease, the adverse effects of drug abuse, and the design of therapeutic agents. He received the Nobel Prize in physiology or medicine jointly with Arvid Carlsson and Eric Kandel (1980). He continued to work on neurotransmission and the broader implications of his findings for other systems, diseases, and drug design. His many awards include the National Academy of Sciences Award in the Neurosciences (1991), the Goodman and Gilman Award in Receptor Pharmacology (1992), and the Lieber Prize for Outstanding Achievement in Schizophrenia Research (1996). (Michael Denman (2nd ed.)

Encyclopedia Judaica. 1971.

Look at other dictionaries:

  • Greengard, Paul — born Dec. 11, 1925, New York, N.Y., U.S. U.S. molecular and cellular biologist. He received his Ph.D. from Johns Hopkins University. Greengard discovered how dopamine and other neurotransmitters work in the nervous system. He showed that slow… …   Universalium

  • Greengard, Paul — (n. 11 dic. 1925, Nueva York, N.Y., EE.UU.). Biólogo celular y molecular estadounidense. Obtuvo su Ph.D. en la Universidad Johns Hopkins. Descubrió cómo la dopamina y otros neurotransmisores operan en el sistema nervioso. Demostró que la… …   Enciclopedia Universal

  • Paul Greengard — (* 11. Dezember 1925 in New York City) ist ein US amerikanischer Biochemiker und Pharmakologe. Im Jahr 2000 erhielt er gemeinsam mit dem Schweden Arvid Carlsson und dem Amerikaner Eric Richard Kandel den Nobelpreis für Medizin und Phy …   Deutsch Wikipedia

  • Paul — /pawl/ for 1 3, 5; /powl/ for 4, n. 1. Saint, died A.D. c67, a missionary and apostle to the gentiles: author of several of the Epistles. Cf. Saul (def. 2). 2. Alice, 1885 1977, U.S. women s rights activist. 3. Elliot (Harold), 1891 1958, U.S …   Universalium

  • paúl — I (Del lat. vulgar padule < lat. palus, paludis , pantano.) ► sustantivo masculino Terreno pantanoso cubierto de hierba. SINÓNIMO paular II (De san Vicente de Paúl.) ► adjetivo/ sustantivo masculino RELIGIÓN Se aplica al clérigo que es miembro …   Enciclopedia Universal

  • Paul Greengard — Saltar a navegación, búsqueda Paul Greengard nació en Nueva York en 1925. Se doctoró en Medicina y Filosofía en la Universidad Johns Hopkins, en Baltimore. Realizó estudios de postdoctorado en Londres, Cambridge, en el Instituto Nacional de… …   Wikipedia Español

  • Paul Greengard — Paul Greengard, né le 11 décembre 1925 à New York (États Unis), est un chercheur américain en neurosciences à l université Rockefeller. Il est, avec Arvid Carlsson et Eric R. Kandel, le co récipiendaire du prix Nobel de physiologie et de médecine …   Wikipédia en Français

  • Greengard — is a surname shared by several notable people:* Paul Greengard (born 1925), American molecular neuroscientist, shared the 2000 Nobel Prize for Physiology or Medicine * Mig Greengard (born 1969), American chess author and journalist …   Wikipedia

  • Greengard — ist der Familienname folgender Personen: Leslie Greengard (* 1958), US amerikanischer Mathematiker Paul Greengard (* 1925), US amerikanischer Biochemiker und Pharmakologe Diese Seite ist eine Begriffsklärung zur Untersche …   Deutsch Wikipedia

  • Greengard —   [ griːngɑːd ], Paul, amerikanischer Biochemiker und Neurophysiologe, * New York 11. 12. 1925; seit 1983 Professor an der Rockefeller University in New York; erforschte v. a. die Einwirkungen von Dopamin und einer Reihe anderer Signalsubstanzen… …   Universal-Lexikon


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.